Host Lipid Transport Protein ORP1 Is Necessary for Coxiella burnetii Growth and Vacuole Expansion in Macrophages

ABSTRACT Coxiella burnetii is an intracellular bacterium that causes the human disease Q fever. C. burnetii forms a large, acidic Coxiella-containing vacuole (CCV) and uses a type 4B secretion system to secrete effector proteins into the host cell cytoplasm. While the CCV membrane is rich in sterols...

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Hlavní autoři:	Baleigh Schuler, Margaret Sladek, Stacey D. Gilk
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2023-06-01
Edice:	mSphere
Témata:	Coxiella ORP membrane contact sites cholesterol intracellular pathogen
On-line přístup:	https://journals.asm.org/doi/10.1128/msphere.00104-23
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