Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment

Cationic gemini surfactants have emerged as potential gene delivery agents as they can co-assemble with DNA due to a strong electrostatic association. Commonly, DNA complexation is enhanced by the inclusion of a helper lipid (HL), which also plays a key role in transfection efficiency. The formation...

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Hauptverfasser:	Isabel S. Oliveira, Sandra G. Silva, Andreia C. Gomes, M. Elisabete C. D. Real Oliveira, M. Luísa C. do Vale, Eduardo F. Marques
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-08-01
Schriftenreihe:	Journal of Functional Biomaterials
Schlagworte:	gemini surfactants serine lipoplex DNA complexation/compaction non-viral gene delivery chain length
Online-Zugang:	https://www.mdpi.com/2079-4983/15/8/224
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