Chaperone mediated autophagy is deficient in spinal motoneurons of ALS patients with TDP-43 proteinopathy

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective loss of motor neurons (MNs), ultimately resulting in paralysis and respiratory failure within 3 to 5 years of onset. Fewer than 10% of ALS cases are familial (fALS), while the vast...

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Autors principals:	Daniel Garrigos, Marta Martinez-Morga, Ana Pombero, Raquel García-Lopez, Diego Pastor, Dolores Riquelme, Miguel Blanquer, Francisca Iniesta, Rut Valdor, Emilio Geijo-Barrientos, Gunnar Hargus, José María Moraleda, Salvador Martínez
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	Motor neurodegeneration sALS Differential vulnerability to neurodegeneration Chaperone mediated autophagy Human motoneurons
Accés en línia:	https://doi.org/10.1186/s40478-026-02238-6
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