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Lipid homeostasis is essential for a maximal ER stress response

Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein and lipid synthesis, making its function essential for both protein and lipid homeostasis. However, it is less clear how lipid m...

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Main Authors: Gilberto Garcia, Hanlin Zhang, Sophia Moreno, C Kimberly Tsui, Brant Michael Webster, Ryo Higuchi-Sanabria, Andrew Dillin
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
lipid homeostasis
proteostasis
ER UPR
stress response
Online Access:https://elifesciences.org/articles/83884
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