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Synaptic Changes in Mice Lacking Alpha- and Gamma-Synucleins

<b>Background:</b> Alpha-synuclein is a key protein involved in the pathogenesis of Parkinson disease (PD). Its intermediate aggregated forms disturb the normal function of dopaminergic (DA) neurons. Furthermore, the loss of intraneuronal connections may precede nerve cell death in PD. Disturbance o...

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Principais autores: Anastasia M. Krayushkina, Olga Morozova, Anastasia Khizeva, Tamara A. Ivanova, Natalia Ninkina, Kirill Chaprov
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-11-01
Serier:Biomedicines
Fag:
Parkinson’s disease
alpha-synuclein
beta-synuclein
gamma-synuclein
striatum
conditional knock-out
Online adgang:https://www.mdpi.com/2227-9059/13/12/2866
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