Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway

The propagation and diversification of signals downstream of the T cell receptor (TCR) involve several adaptor proteins that control the assembly of multimolecular signaling complexes (signalosomes). The global characterization of changes in protein-protein interactions (PPI) following genetic pertu...

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Autors principals:	Kilian Ruminski, Javier Celis-Gutierrez, Nicolas Jarmuzynski, Emilie Maturin, Stephane Audebert, Marie Malissen, Luc Camoin, Guillaume Voisinne, Bernard Malissen, Romain Roncagalli
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	TCR SLP76 GRB2-family adaptors mass spectrometry T cell signaling
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139123/full
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