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Cyclosporine A inhibits MRTF‐SRF signaling through Na+/K+ ATPase inhibition and actin remodeling

Abstract Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ technology) to highlight new targets of CNI in renal pr...

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Principais autores: Bastien Burat, Quentin Faucher, Petra Čechová, Hélène Arnion, Florent Di Meo, François‐Ludovic Sauvage, Pierre Marquet, Marie Essig
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2019-09-01
Serier:FASEB BioAdvances
Fag:
actin cytoskeleton
cofilin
cyclosporine A
MRTF‐SRF
Na+/K+‐ATPase
Online adgang:https://doi.org/10.1096/fba.2019-00027
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