Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing

Previously, we showed that Saccharomyces cerevisiae Chd1 chromatin remodelling enzyme associates with nucleosomes oriented towards the longer linker (Sundaramoorthy et al., 2018) (1). Here, we report a series of structures of Chd1 bound to nucleosomes during ongoing ATP-dependent repositioning. Comb...

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Detalles Bibliográficos

Autores principales:	Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2025-12-01
Colección:	eLife
Materias:	nucleosome positioning ATP-dependent chromatin remodeling chromatin structure
Acceso en línea:	https://elifesciences.org/articles/52513
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