Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy

Idebenone (IDE), a strong antioxidant widely investigated for the treatment of neurodegenerative diseases and skin disorders, shows low oral and topical bioavailability due to its unfavorable physico-chemical properties. In this work, to improve IDE topical effectiveness, we explored a two-steps app...

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Detalhes bibliográficos

Principais autores:	Lucia Montenegro, Anna Maria Panico, Ludovica Maria Santagati, Edy Angela Siciliano, Sebastiano Intagliata, Maria N. Modica
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2018-12-01
coleção:	Nanomaterials
Assuntos:	idebenone solid lipid nanoparticles nanocarriers pyroglutamic acid idebenone derivative antioxidant activity ORAC assay anti-glycation activity skin hydration
Acesso em linha:	http://www.mdpi.com/2079-4991/9/1/43
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