RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Abstract Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m1A levels were assessed through liqu...

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Bibliografski detalji

Glavni autori:	Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-12-01
Serija:	Cancer Communications
Teme:	Colorectal Cancer Therapeutic target TRMT61A MAPK/ERK N1‐Methyladenosine
Online pristup:	https://doi.org/10.1002/cac2.70070
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