Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer

Abstract Background Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell proliferation and resistance to chemotherapy. Accordingly, we investigated...

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Principais autores:	Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki, Ken-Ichiro Yoshida
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2019-11-01
Series:	BMC Cancer
Assuntos:	Nuclear factor erythroid 2–related factor 2 (Nrf2) Kelch-like ECH-associated protein 1 (Keap1) Single nucleotide polymorphism Renal cell carcinoma
Acceso en liña:	http://link.springer.com/article/10.1186/s12885-019-6347-0
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