The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the denuded axons. Virtually all treatments for M...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Mohanlall Narine, Maryam A. Azmi, Martin Umali, Ashley Volz, Holly Colognato
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-10-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	metformin oligodendrocyte metabolism cuprizone multiple sclerosis myelin repair
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1254303/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!