First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

Abstract Background Imaging of cell death can provide an early indication of treatment response in cancer. [99mTc]Tc-Duramycin is a small-peptide SPECT tracer that recognizes both apoptotic and necrotic cells by binding to phosphatidylethanolamine present in the cell membrane. Preclinically, this tr...

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Principais autores:	Taco Metelerkamp Cappenberg, Stijn De Schepper, Christel Vangestel, Stef De Lombaerde, Leonie wyffels, Tim Van den Wyngaert, Jeffrey Mattis, Brian Gray, Koon Pak, Sigrid Stroobants, Filipe Elvas
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2023-08-01
Series:	EJNMMI Radiopharmacy and Chemistry
Assuntos:	Cell death imaging Apoptosis 99mTc-duramycin SPECT Biodistribution Internal dosimetry
Acceso en liña:	https://doi.org/10.1186/s41181-023-00207-1
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