GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus

Abstract Background The etiology of gestational diabetes mellitus (GDM) is constituted by both type 2 diabetes (T2D)-dependent and T2D-independent mechanisms. However, existing studies have evaluated the impact of T2D-dependent loci only for GDM, which limits the power to assess to what extent genet...

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Hlavní autoři:	Siquan Zhou, Zhichang Ran, Yanliu Li, Jiayuan He, Xin Yuan, Yuanqi Hu, Xiaoyu Wang, Ruirui Li, Yujie Xu, Ciling Yan, Jingyuan Xiong, Guo Cheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Genome Medicine
Témata:	Gestational diabetes mellitus Type 2 diabetes GWAS-by-subtraction Genome-wide association study Genomic structural equation model
On-line přístup:	https://doi.org/10.1186/s13073-026-01674-2
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