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Mechanisms of Berberine in anti-pancreatic ductal adenocarcinoma revealed by integrated multi-omics profiling

Abstract This study integrates pharmacology databases with bulk RNA-seq and scRNA-seq to reveal the latent anti-PDAC capacities of BBR. Target genes of BBR were sifted through TargetNet, CTD, SwissTargetPrediction, and Binding Database. Based on the GSE183795 dataset, DEG analysis, GSEA, and WGCNA w...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jia Yang, Tingting Xu, Hongwei Wang, Lei Wang, Yanmei Cheng
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2024-10-01
Rangatū:Scientific Reports
Ngā marau:
Urunga tuihono:https://doi.org/10.1038/s41598-024-74943-y
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