Characterization of the KRas G12D-inhibitor interactions by differential HDX-MS and molecular dynamics simulations
Hydrogen-deuterium exchange (HDX) combined with mass spectrometry (MS) is a powerful technique for studying changes in protein structure and dynamics upon ligand binding. Protein-ligand complexes can result in increased protection of peptide-bond amides in HDX indicating protein structure stabilizat...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Association for the Advancement of Science (AAAS)
2025-01-01
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| Collection: | Computational and Structural Biotechnology Journal |
| Sujets: | |
| Accès en ligne: | http://www.sciencedirect.com/science/article/pii/S2001037025003307 |
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