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Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

Elevated Cx37 expression in endothelium stabilizes nuclear Foxo3a by sequestering active ERK in the cytoplasm, thereby up-regulating p27 expression to promote late G1 state and enable arterial gene expression. Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest l...

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Автори: Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi
Формат: Artigo
Мова:Inglês
Опубліковано: Life Science Alliance LLC 2023-08-01
Серія:Life Science Alliance
Онлайн доступ:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201685
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