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Safety and effectiveness of phenobarbital vs. benzodiazepines for severe alcohol withdrawal in alcohol-associated liver disease in the ICU

Background & Aims: Severe alcohol withdrawal syndrome (SAWS) in patients with alcohol-associated liver disease (ALD) presents management challenges due to altered drug metabolism and increased toxicity. While benzodiazepines remain standard therapy, concerns about drug shortages, over-sedation,...

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Principais autores: Rajalakshmi Govalan, Shengchen Hao, Michael T. Kenes, Jakob I. McSparron, Elliot B. Tapper
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-04-01
coleção:JHEP Reports
Assuntos:
Severe alcohol withdrawal syndrome
phenobarbital
benzodiazepines
alcohol-associated liver disease
critical care
mechanical ventilation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589555926000406
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