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Miltefosine and Benznidazole Combination Improve Anti-Trypanosoma cruzi In Vitro and In Vivo Efficacy

Drug repurposing and combination therapy have been proposed as cost-effective strategies to improve Chagas disease treatment. Miltefosine (MLT), a synthetic alkylphospholipid initially developed for breast cancer and repositioned for leishmaniasis, is a promising candidate against Trypanosoma cruzi...

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Principais autores: Julián Ernesto Nicolás Gulin, Margarita María Catalina Bisio, Daniela Rocco, Jaime Altcheh, María Elisa Solana, Facundo García-Bournissen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-07-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
Chagas disease
Trypanosoma cruzi
miltefosine
benznidazole
drug combination chemotherapy
drug repositioning
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2022.855119/full
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