Structural characterization of kappa-opioid receptor dimer in complex with two G proteins

Abstract The κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive. Here, we demonstrate stable κOR dimer formation...

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Hlavní autoři:	Yuxi Zhao, Chanjuan Xu, Yue Wang, Hong Shan, Jing Wang, Yuxuan Liu, Xin Luo, Junrui Li, Mingyang Li, Yini Liu, Kai Wu, Bryan L. Roth, Xi-Ping Huang, H. Eric Xu, Jianfeng Liu, Youwen Zhuang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-73615-x
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