In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1

Abstract Benzodiazepines are widely recognized for their therapeutic benefits in the treatment of anxiety and insomnia. However, in the pursuit of innovative anticancer agents, they have gained attention as a possible pharmacophore. One of those promising anticancer benzodiazepines is 3b which was d...

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Prif Awduron:	Nada S. Al-Theyab, Ahmad H. Bakheit, Sanae Lahmidi, Mohammed Mufadhe Alanazi, Awadh M Ali, Khalil Azzaoui, El Mokhtar Essassi, Joel T. Mague, Mohamad Hefnawy, Mohammed Mater Alanazi, Ashwag S. Alanazi
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2025-04-01
Cyfres:	Scientific Reports
Pynciau:	Benzodiazepine HDAC inhibitor, HER2 inhibitor Cell cycle analysis Programed cell death Molecular dynamics simulations
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-025-97786-7
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