Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells

A brief in vitro stimulation of natural killer (NK) cells with interleukin (IL)-12, IL-15, and IL-18 endow them a memory-like behavior, characterized by higher effector responses when they are restimulated after a resting period of time. These preactivated NK cells, also known as cytokine-induced me...

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Autors principals:	Iñigo Terrén, Idoia Mikelez, Irati Odriozola, Andrea Gredilla, Javier González, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco Borrego
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	natural killer cells ruxolitinib memory-like natural killer cells cytokine preactivation cytokine production polyfunctionality
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00737/full
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