TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition
The findings shed light into the adverse effects of GSIs observed in the Alzheimer’s field and explain, at least in part, the unexpected worsening in cognition observed in the semagacestat Phase 3 trial. γ-secretase inhibitors (GSI) were developed to reduce the generation of Aβ peptide to find new A...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Life Science Alliance LLC
2021-04-01
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| coleção: | Life Science Alliance |
| Acesso em linha: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000844 |
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