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Orexins, Psychosis, and Antipsychotics: A Systematic Review of Studies of Orexin Levels and the Effects of Dual Orexin Receptor Antagonists (DORAs)

<b>Background/Objectives</b>: Schizophrenia is a severe psychiatric disorder frequently characterised by sleep and circadian disturbances, which are closely linked to cognitive dysfunction, symptom exacerbation, and poor functional outcomes. A growing body of evidence implicates the orexin (hypocret...

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Principais autores: Stella Margoni, Senad Hasaj, Guglielmo Donofrio, Georgios D. Kotzalidis, Tommaso Callovini, Mario Pinto, Camilla Scialpi, Matteo Bucci, Maria Benedetta Anesini, Gabriele Sani, Lorenzo Moccia, Delfina Janiri
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Brain Sciences
Fag:
schizophrenia
orexin/hypocretin system
antipsychotic drugs
sleep
dual orexin receptor antagonists
psychosis
Online adgang:https://www.mdpi.com/2076-3425/16/4/361
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