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SIRT1: A likely key for future therapeutic strategies for pain management

Sirtuin 1 (SIRT1), a NAD+ -dependent histone deacetylase, plays a crucial role in mitigating oxidative stress, regulating inflammation, and maintaining mitochondrial function. Reduced SIRT1 activity has been linked to elevated pro-inflammatory cytokines, mitochondrial dysfunction, and chronic pain,...

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Autori principali: Sara Ilari, Saverio Nucera, Lucia Carmela Passacatini, Rosamaria Caminiti, Valeria Mazza, Roberta Macrì, Maria Serra, Federica Scarano, Valentina Malafoglia, Ernesto Palma, Francesca Oppedisano, Jessica Maiuolo, Carlo Tomino, Vincenzo Mollace, Carolina Muscoli
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-03-01
Serie:Pharmacological Research
Soggetti:
Inflammation
sirtuin 1 (SIRT1)
Natural antioxidants
Polyphenolic fraction of bergamot (BPF)
Oxidative stress
Accesso online:http://www.sciencedirect.com/science/article/pii/S1043661825000957
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