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Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice

We have recently demonstrated that neural stem cell-based intravitreal co-administration of glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) confers profound protection to injured retinal ganglion cells (RGCs) in a mouse optic nerve crush model, resulting in...

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Main Authors: Simon Dulz, Mahmoud Bassal, Kai Flachsbarth, Kristoffer Riecken, Boris Fehse, Stefanie Schlichting, Susanne Bartsch, Udo Bartsch
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
axotomy
CNTF
GDNF
lentiviral vectors
neural stem cells
neuroprotection
Online Access:https://www.mdpi.com/2073-4409/9/9/2082
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