KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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主要な著者:	Mattia Ficarelli, Harry Wilson, Rui Pedro Galão, Michela Mazzon, Irati Antzin-Anduetza, Mark Marsh, Stuart JD Neil, Chad M Swanson
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2019-07-01
シリーズ:	eLife
主題:	HIV CpG dinucleotide ZAP TRIM25 KHNYN innate immunity
オンライン･アクセス:	https://elifesciences.org/articles/46767
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