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Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform

Abstract The intestinal mucosa is a complex functional layer which is formed from a diverse range of cell types that include epithelial cells (within crypts and villi) and an array of mesenchymal cells. Many intestinal diseases involve loss of the surface mucosa which can be difficult to restore, an...

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Principais autores: William Dalleywater, Alexander V. Predeus, Batuhan Cakir, Pavel Mazin, Jayakumar Vadakekolathu, Sergio Rutella, Marian L. Meakin, Alison A. Ritchie, Shamir Montazid, Sara Cuevas Ocaña, Nadine Holmes, Victoria Wright, Fei Sang, Silvia Santoni, Adam Bills, Declan Sculthorpe, Rasa Elmentaite, Sarah A. Teichmann, Shazia Irshad, Ian Tomlinson, Andrew Silver, Ricky D. Wildman, Nicholas R. F. Hannan, Felicity R. A. J. Rose, Mohammad Ilyas
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-04-01
coleção:Stem Cell Research & Therapy
Assuntos:
Induced pluripotent stem cells
Intestine
Colon
Co-differentiation
Tissue engineering
Acesso em linha:https://doi.org/10.1186/s13287-026-05006-4
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