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Safety of dabigatran in patients with atrial fibrillation and chronic kidney disease: pharmacokinetic and pharmacogenetic aspects

Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD). This study was aimed to evaluate relationships between CES1 and ABCB1 polymorphism, dabigatran...

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Sábháilte in:
Príomhchruthaitheoirí: A. I. Skripka, P. O. Bochkov, K. A. Akmalova, R. V. Shevchenko, P. M. Krupenin, V. V. Kogay, A. I. Listratov, A. S. Krainyaya, D. A. Napalkov, O. S. Gurinovich, A. A. Sokolova, V. V. Fomin, D. A. Sychev
Formáid: Artigo
Teanga:Russo
Foilsithe / Cruthaithe: Remedium Group LLC 2020-01-01
Sraith:Медицинский совет
Ábhair:
doac
dabigatran
atrial fibrillation
chronic kidney disease
hemorrhagic events
abcb1
ces1
rs1045642
rs2244613
rs4148738
pharmacokinetics
pharmacogenetics
Rochtain ar líne:https://www.med-sovet.pro/jour/article/view/5476
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