MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism

Abstract Diabetic nephropathy (DN), the leading cause of end-stage renal disease, lacks effective therapies due to an incomplete understanding of its cell-type-specific pathogenesis. Here, through an integrative multi-omics approach, we have decoded the molecular architecture of DN, identify novel t...

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Detalhes bibliográficos

Principais autores:	Shi Qiu, Dandan Xie, Sifan Guo, Zhibo Wang, Ying Cai, Xian Wang, Zhencai Hu, Shiwei Wang, Chunsheng Lin, Hong Yao, Qiang Yang, Yu Guan, Qiqi Zhao, Songqi Tang, Wenjie Sun, Yiqiang Xie, Aihua Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-03-01
coleção:	Cell Death Discovery
Acesso em linha:	https://doi.org/10.1038/s41420-026-02990-7
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