PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome

APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI). We previously showed that bacterially-express...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Anisur Rahman
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2018-10-01
سلاسل:	Frontiers in Immunology
الموضوعات:	antiphospholipid syndrome PEGylation domain I therapeutics biologics
الوصول للمادة أونلاين:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02413/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!