Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis[S]

Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the “high-capacity binding site” (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Here, using sucrose gradient fractionation, we obtained evidence that both ABCA1 and [125I]apoA-I...

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Detalhes bibliográficos

Principais autores:	Iulia Iatan, Dana Bailey, Isabelle Ruel, Anouar Hafiane, Steven Campbell, Larbi Krimbou, Jacques Genest
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2011-11-01
coleção:	Journal of Lipid Research
Assuntos:	lipid and lipoprotein metabolism high-capacity binding site PtdCho-rich microdomains rafts HDL formation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S002222752035094X
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