A novel cell source for therapy of knee osteoarthritis using atelocollagen microsphere-adhered adipose-derived stem cells: Impact of synovial fluid exposure on cell activity

Introduction: Administration of adipose-derived stem cells (ADSCs) into the joint cavity has been shown to alleviate the symptoms of knee osteoarthritis (OA) by releasing exosomes and anti-inflammatory cytokines. However, the therapeutic effect of these cells is limited by their rapid disappearance...

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Principais autores:	Takuya Sakamoto, Atsushi Fuku, Tetsuhiro Horie, Hironori Kitajima, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Yasuo Iida, Sohsuke Yamada, Naoki Yamamoto, Yusuke Shimizu, Yasuhito Ishigaki, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-12-01
Colecção:	Regenerative Therapy
Assuntos:	Adipose-derived stem cell Atelocollagen microsphere Knee osteoarthritis Exosome IL-10 RNA-seq
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352320424000725
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