TXA11114: Discovery of an <i>In Vivo</i> Efficacious Efflux Pump Inhibitor (EPI) That Potentiates Levofloxacin Against <i>Pseudomonas aeruginosa</i>

<b>Objectives:</b> Multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> represents a major clinical challenge, driven in part by resistance–nodulation–division (RND) efflux pumps that reduce intracellular antibiotic concentrations and limit the efficacy of many antibacterial agents, including flu...

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Autors principals:	Jesus D. Rosado-Lugo, Pratik Datta, Ahmad Altiti, Yongzheng Zhang, Jun Lu, Yi Yuan, Ajit K. Parhi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-03-01
Col·lecció:	Antibiotics
Matèries:	<i>P. aeruginosa</i> RND efflux pumps antimicrobial drug resistance efflux pump inhibitor indole carboxamide <i>in vivo</i> efficacy
Accés en línia:	https://www.mdpi.com/2079-6382/15/4/346
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