Bulky PP1 analogs exert cellular effects independently from analog-sensitive kinase inhibition

To circumvent the general lack of selectivity of protein kinase inhibitors, a chemical genetics approach has been developed to allow the selective targeting of engineered kinases by bulky ATP analogs, most of which derived from the pyrazolo[3,4-d]pyrimidine 1 (PP1) inhibitor. Although designed to se...

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Principais autores:	Coralie Gicquel, Sabine Genicot, Arnaud Comte, Pierre Colas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Chemistry
Assuntos:	analog-sensitive kinase chemical genetics non-specific cellular effects PP1 analogs protein kinase inhibition
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fchem.2026.1812827/full
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