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Taxifolin protects ovarian tissue from methotrexate-induced injury by targeting TGF-β/BMP-7 pathways

Abstract Objective This study aimed to evaluate the protective effect of taxifolin on methotrexate (MTX)-induced ovarian toxicity in a rat model. Given the increasing clinical use of MTX and its known detrimental effects on ovarian function, identifying effective protective strategies is crucial for...

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Wedi'i Gadw mewn:
Prif Awduron: Bakiye Akbaş, Gülseren Dinç, Ahmet Akbaş, Gulcin Ercan, Hatice Aygün, Oytun Erbas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2026-01-01
Cyfres:Journal of Ovarian Research
Pynciau:
Methotrexate
Taxifolin
Ovarian toxicity
Oxidative stress
Inflammation
Folliculogenesis
Mynediad Ar-lein:https://doi.org/10.1186/s13048-025-01949-z
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