Developability Evaluation of Single-Domain Antibody-Chelator Conjugates for Diagnostic Radiotracers

<b>Background/Objectives</b>: Developability assessment is a critical step in advancing antibody-based molecules toward clinical application. This evaluation typically begins during clinical candidate selection and continues throughout all modifications of the molecule during development. It is guid...

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Główni autorzy:	Philipp D. Kaiser, Simon Straß, Sandra Maier, Evgenia Herbold, Bjoern Traenkle, Anne Zeck
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2026-03-01
Seria:	Antibodies
Hasła przedmiotowe:	single-domain antibodies (sdAbs) developability assessment chelator conjugates (NODAGA) chelatability (Cu<sup>2+</sup> radiolabeling efficiency) dynamic light scattering (DLS) liquid chromatography-mass spectrometry (LC–MS)
Dostęp online:	https://www.mdpi.com/2073-4468/15/2/22
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