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Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H+)-ATPase Inhibitors

The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps and they have been associated with cancer invasion, metastasis, and drug resistance. Despite the clear involvement of V-ATPases in cancer, the therapeutic use of V-ATPase-targeting small molecules has not reached human cli...

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Principais autores: Renukadevi Patil, Arpita Kulshrestha, Anjali Tikoo, Sara Fleetwood, Gajendra Katara, Bala Kolli, William Seibel, Alice Gilman-Sachs, Shivaputra A. Patil, Kenneth D. Beaman
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-09-01
Serier:Molecules
Fag:
vacuolar (H+)-ATPase (V-ATPase)
inhibitor
bisbenzimidazole
breast cancer
ovarian cancer
antiproliferative activity
proton (H+) pump activity
Online adgang:https://www.mdpi.com/1420-3049/22/9/1559
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