Interpreting cancer genetics through a two-step “evolutionary cascade hypothesis”: bridging neutral and selective perspectives

Abstract Background DNA mutations are the fundamental engines of cancer, driving its initiation and progression. The forces that fuel malignancy are also the architects of evolution, shaping life through genetic variations. Mutations, in fact, can emerge naturally from endogenous processes, such as...

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Principais autores:	Alessandro Ottaiano, Mariachiara Santorsola, Francesco Sabbatino, Roberto Sirica, Francesco Caraglia, Anna Ceccarelli, Vincenza Granata, Ines Simeone, Silvia Zappavigna, Massimiliano Berretta, Giovanni Savarese, Michele Caraglia
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2026-02-01
סדרה:	Journal of Translational Medicine
נושאים:	Cancer evolution Cancer genetics DNA mutations Genomic instability DNA repair
גישה מקוונת:	https://doi.org/10.1186/s12967-026-07869-w
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