Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

Aldose reductase (ALDR) is a critical protein involved in the pathogenesis of diabetic complications such as retinopathy, neuropathy, and nephropathy. Due to the activation of inflammatory and cytotoxic pathways under hyperglycemic conditions, ALDR has become an important target for therapeutic deve...

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Autori principali:	Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley-VCH 2025-12-01
Serie:	ChemistryOpen
Soggetti:	aldose reductase inhibitors binding affinity diabetic neuropathy molecular dynamics simulations virtual screening
Accesso online:	https://doi.org/10.1002/open.202500110
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