Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells

Abstract Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in transcription consistent with the repression of g...

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主要な著者:	John N. Mariani, Benjamin Mansky, Pernille M. Madsen, Dennis Salinas, Deniz Kesmen, Nguyen P. T. Huynh, Nicholas J. Kuypers, Erin R. Kesel, Janna Bates, Casey Payne, Devin Chandler-Militello, Abdellatif Benraiss, Steven A. Goldman
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2024-05-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-024-48118-2
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