Frequency of extractable nuclear antigen seropositivity among individuals seronegative for antinuclear antibodies on indirect immunofluorescence: a systematic review and meta-analysis

BackgroundThe frequency of extractable nuclear antigen (ENA) seropositivity in patients with negative antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) remains insufficiently characterized. We aimed to estimate the frequency of ENA seropositivity among ANA-IIF–negative individuals (E...

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Hlavní autoři:	Tarak Dhaouadi, Imen Zamali, Ahlem Ben Hmid, Mariem Guizani, Awatef Riahi, Taieb Ben Abdallah, Samar Samoud, Yousr Gorgi, Yousr Galai, Imen Sfar, Mélika Ben Ahmed
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-04-01
Edice:	Frontiers in Immunology
Témata:	antinuclear antibody connective tissue disease extractable nuclear antigens indirect immunofluorescence meta-analysis meta-regression
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1745828/full
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