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Identification of IKZF1 genetic mutations as new molecular subtypes in acute myeloid leukaemia

Abstract Background Genetic mutations of IKZF1 have been frequently delineated in B‐lineage acute leukaemia (B‐ALL) but rarely elucidated in acute myeloid leukaemia (AML). IKZF1 mutations confer a poor prognosis in AML, and hotspot mutations of IKZF1, N159Y and N159S tend to occur in B‐ALL and AML r...

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Principais autores: Yang Wang, Wenyan Cheng, Yvyin Zhang, Yuliang Zhang, Tengfei Sun, Yongmei Zhu, Wei Yin, Jianan Zhang, Jianfeng Li, Yang Shen
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2023-06-01
coleção:Clinical and Translational Medicine
Assuntos:
acute myeloid leukaemia
DNA binding
gene expression profiles
IKZF1
sequence variants
Acesso em linha:https://doi.org/10.1002/ctm2.1309
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