Oral Immunization with the C488A Live-Attenuated Mutant of Coxsackievirus B4E2 (CVB4E2) Induces Potent Immune Response and Protects Balb/c Mice Against Lethal Infection

Background/Objectives: Coxsackievirus B4 (CVB4), a member of the <i>Enterovirus</i> genus and the <i>Picornaviridae</i> family, is a significant pathogen causing several human diseases such as pancreatitis, myocarditis, cardiomyopathy and type 1 diabetes. Despite its clinical impact, no vaccines or...

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Principais autores:	Jawhar Gharbi, Ikbel Hadj Hassine, Mouna Hassine, Anwar Al-Bashir, Reem Al-Chahri, Ameera Al-Yami, Mohamed Al-Malki, Noureddine Chatti, Didier Hober, Manel Ben M’hadheb
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2026-02-01
Series:	Viruses
Assuntos:	CVB4 replication translation virulence live-attenuated mutant vaccine
Acceso en liña:	https://www.mdpi.com/1999-4915/18/2/228
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