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Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach.

Senescent endothelial cells (EC) are key players in the pathophysiology of cardiovascular diseases and are characterized by a reduced angiogenic and regenerative potential. Therefore, targeting these cells has been suggested as an effective therapeutic strategy to reduce vascular disease burden and...

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Autori principali: Katrin Kalies, Kai Knöpp, Susanne Koch, Claudia Pilowski, Leonie Wurmbrand, Daniel Sedding
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2025-01-01
Serie:PLoS ONE
Accesso online:https://doi.org/10.1371/journal.pone.0319381
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