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Efficacy and safety of PI3K inhibitors combined with fulvestrant for HR+/HER2− advanced breast cancer: a systematic review and meta-analysis

ObjectivesThis systematic review and meta-analysis aimed to evaluate the efficacy and safety of combination of Phosphatidylinositol 3-kinase (PI3K) inhibitors and fulvestrant in patients with advanced breast cancer (ABC) who are hormone receptor-positive (HR+) and human epidermal growth factor recep...

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Principais autores: Xuefeng Li, Hongxian Wang, Shuhui Lin, Tianwen Chen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-06-01
Serier:Frontiers in Oncology
Fag:
PI3K inhibitors
advanced breast cancer
progression-free survival
PIK3CA mutations
meta-analysis
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1556978/full
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