A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.

Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect asso...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul I W de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Public Library of Science (PLoS) 2014-07-01
سلاسل:	PLoS Genetics
الوصول للمادة أونلاين:	https://doi.org/10.1371/journal.pgen.1004469
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!