Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment

Abstract The toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP), a functional analysis of the effect...

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Detalhes bibliográficos

Principais autores:	Fatima Abbas, Laila Ananda Blömer, Hugo Millet, Jérôme Montnach, Michel De Waard, Marco Canepari
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-02-01
coleção:	Scientific Reports
Assuntos:	AaH-II toxin Voltage-gated sodium channels Axon initial segment Action potential Neocortical layer-5 pyramidal neuron Calcium
Acesso em linha:	https://doi.org/10.1038/s41598-024-55315-y
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