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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy

Summary: Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time...

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Asıl Yazarlar: Wee Loong Chin, Alistair M. Cook, Jonathan Chee, Nicola Principe, Tracy S. Hoang, Joel Kidman, Khaing P.W. Hmon, Yen Yeow, Matthew E. Jones, Rui Hou, Elena Denisenko, Alison M. McDonnell, Chung-Chau Hon, Jonathan Moody, Denise Anderson, Sonia Yip, Michelle M. Cummins, Martin R. Stockler, Peey-Sei Kok, Chris Brown, Thomas John, Steven C.-H. Kao, Deme J. Karikios, Kenneth J. O’Byrne, Brett G.M. Hughes, Richard A. Lake, Alistair R.R. Forrest, Anna K. Nowak, Timo Lassmann, W. Joost Lesterhuis
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-01-01
Seri Bilgileri:Cell Reports Medicine
Konular:
immune checkpoint therapy
ICT
platinum chemotherapy
mesothelioma
single-cell RNA sequencing
biomarkers
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2666379124006530
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