Gdf15 expression in thermogenic adipocytes regulates diet-induced weight gain in a sex-dependent manner

Abstract Background Growth differentiation factor 15 (GDF15) is a stress-induced cytokine known to bind to its endogenous receptor GDNF-family α-like (GFRAL) in the hindbrain, thereby modulating energy homeostasis. In response to prolonged high-fat diet (HFD) feeding, Gdf15 expression is induced in...

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Autors principals:	Jayashree Jena, Ayushi Sood, Joshua Peterson, Luis Miguel García-Peña, Eric T. Weatherford, Pritesh Patel, Shelly Roitershtein, David A. Smith, Vamsi Challa, Randy J. Seeley, Renata O. Pereira
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-05-01
Col·lecció:	Molecular Medicine
Matèries:	GDF15 Obesity Brown adipose tissue Sex dimorphism
Accés en línia:	https://doi.org/10.1186/s10020-026-01505-5
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